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[The experimental anti-arrhythmia properties of the histamine H1 receptor blockader fencarol].

Abstract
Phencarol, a blocker of H1-histamine receptors, is used as an antihistaminic agent. The antiarrhythmic effect of phencarol was detected and studied on experimental models of arrhythmias in non-anesthetized rabbits in a dose of 5 mg/kg intravenously. The drug was shown to possess the pronounced antiarrhythmic and protective properties on the models of calcium-chloride-, adrenaline- and strophanthine-induced arrhythmias and to exert no influence on aconitine-induced arrhythmia. Phencarol was demonstrated to have no cardiodepressive effect.
AuthorsG M Iakovlev, V I Skorobogatov, A S Svistov, M I Mironova
JournalFarmakologiia i toksikologiia (Farmakol Toksikol) 1991 Sep-Oct Vol. 54 Issue 5 Pg. 25-7 ISSN: 0014-8318 [Print] Russia (Federation)
Vernacular TitleAntiaritmicheskie svoĭstva blokatora H1-gistaminovykh retseptorov fenkarola v éksperimente.
PMID1686869 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Arrhythmia Agents
  • Benzhydryl Compounds
  • Histamine H1 Antagonists
  • quifenadine
Topics
  • Animals
  • Anti-Arrhythmia Agents (adverse effects, therapeutic use)
  • Arrhythmias, Cardiac (chemically induced, drug therapy, physiopathology)
  • Benzhydryl Compounds (adverse effects, therapeutic use)
  • Drug Evaluation, Preclinical
  • Electrocardiography (drug effects)
  • Heart Rate (drug effects)
  • Histamine H1 Antagonists (adverse effects, therapeutic use)
  • Male
  • Rabbits

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