Abstract |
Phencarol, a blocker of H1-histamine receptors, is used as an antihistaminic agent. The antiarrhythmic effect of phencarol was detected and studied on experimental models of arrhythmias in non-anesthetized rabbits in a dose of 5 mg/kg intravenously. The drug was shown to possess the pronounced antiarrhythmic and protective properties on the models of calcium-chloride-, adrenaline- and strophanthine-induced arrhythmias and to exert no influence on aconitine-induced arrhythmia. Phencarol was demonstrated to have no cardiodepressive effect.
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Authors | G M Iakovlev, V I Skorobogatov, A S Svistov, M I Mironova |
Journal | Farmakologiia i toksikologiia
(Farmakol Toksikol)
1991 Sep-Oct
Vol. 54
Issue 5
Pg. 25-7
ISSN: 0014-8318 [Print] Russia (Federation) |
Vernacular Title | Antiaritmicheskie svoĭstva blokatora H1-gistaminovykh retseptorov fenkarola v éksperimente. |
PMID | 1686869
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Arrhythmia Agents
- Benzhydryl Compounds
- Histamine H1 Antagonists
- quifenadine
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Topics |
- Animals
- Anti-Arrhythmia Agents
(adverse effects, therapeutic use)
- Arrhythmias, Cardiac
(chemically induced, drug therapy, physiopathology)
- Benzhydryl Compounds
(adverse effects, therapeutic use)
- Drug Evaluation, Preclinical
- Electrocardiography
(drug effects)
- Heart Rate
(drug effects)
- Histamine H1 Antagonists
(adverse effects, therapeutic use)
- Male
- Rabbits
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