Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: a cross-sectional study.

Abstract

BACKGROUND:

Primary hyperparathyroidism (PHPT) is associated with reduced plasma 25-hydroxyvitamin D (P-25OHD) and usually increased plasma 1alpha,25-dihydroxyvitamin D (P-1,25(OH)2D). Parathyroid tissue expresses the vitamin D receptor and it is thought that circulating 1,25(OH)2D participate in the regulation of parathyroid cell proliferation, differentiation and secretion.

AIM:

To investigate the relations between circulating levels of 1,25(OH)2D and 25OHD respectively and parathyroid adenoma weight (AW), plasma-parathyroid hormone (P-PTH) and PTH secretion expressed as P-PTH/AW.

DESIGN:

Cross-sectional study.

MATERIAL:

One hundred and seventy-one consecutive hypercalcaemic caucasian patients aged 19-87 years (median 63, 84% females) with surgically proven parathyroid adenoma.

RESULTS:

A weak positive correlation was found between P-25OHD and P-1,25(OH)2D (r=0.24, P<0.005). AW depended on sex and body mass index. Following adjustment, it was correlated positively to P-PTH, calcium (Ca) and alkaline phosphatase (AP) and inversely to plasma phosphate in a multiple regression model. AW was not associated with vitamin D metabolites. Preoperative P-PTH correlated positively to plasma levels of Ca and AP, but inversely to phosphate and 25OHD (P<0.001) levels. P-PTH was not associated with P-1,25(OH)2D (P=0.65). The P-PTH:AW ratio correlated inversely to P-25OHD (P<0.05), but showed no relations to plasma levels of Ca, phosphate or 1,25(OH)2D (P=0.22).

CONCLUSION:

In this material, low levels of 25OHD were related to higher levels of P-PTH and higher PTH:AW ratios in patients with PHPT suggesting that vitamin D deficiency increase PTH secretion activity. Neither PTH secretion nor AW was associated with circulating levels of 1,25(OH)2D.

• Authors: B Moosgaard, P Vestergaard, L Heickendorff, F Melsen, P Christiansen, L Mosekilde
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 155 Issue 2 Pg. 237-44 (Aug 2006) ISSN: 0804-4643 [Print] England
• PMID: 16868136 (Publication Type: Journal Article)

Chemical References

• Parathyroid Hormone
• Vitamin D
• 1,25-dihydroxyvitamin D
• 25-hydroxyvitamin D

Topics

• Adenoma (blood, complications, pathology)
• Adult
• Aged
• Aged, 80 and over
• Cross-Sectional Studies
• Female
• Humans
• Hyperparathyroidism, Primary (blood, etiology, pathology)
• Male
• Middle Aged
• Organ Size
• Parathyroid Glands (metabolism, pathology)
• Parathyroid Hormone (blood, metabolism)
• Parathyroid Neoplasms (blood, complications, pathology)
• Vitamin D (analogs & derivatives, blood, pharmacokinetics)
• Vitamin D Deficiency (blood, pathology)