[Effects of buspirone and buspirone-like 1-A-agonists of serotonin on the level of systemic blood pressure].

Abstract

Experiments on anaesthetized rats showed that buspirone, its structural analogies (ipsapirone, campirone and levopirone) and active metabolite 1-(2-pyrimidinyl)-piperazine (0.1-30 mg/kg i.v.) produced bradycardia, hyperpnea and changed the arterial pressure level. Arterial pressure either increased or decreased that was determined by its initial level. The hypotension produced by all these drugs was of a central origin and mediated by hydroxytryptamine-1A-receptors. The pressor response resulted from activation of predominantly hydroxytryptamine-2-receptors of vascular smooth muscles.

• Authors: I V Komissarov, A V Mamonov, I T Filippov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 112 Issue 7 Pg. 62-4 (Jul 1991) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie buspirona i buspironopodobnykh 1A-agonistov serotonina na uroven' sistemnogo arterial'nogo davleniia.
• PMID: 1686564 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Anxiety Agents
• Receptors, Serotonin
• 1-(2-pyrimidinyl)piperazine
• Buspirone

Topics

• Animals
• Anti-Anxiety Agents (pharmacology)
• Blood Pressure (drug effects)
• Buspirone (analogs & derivatives, pharmacology)
• Muscle, Smooth, Vascular (drug effects)
• Rats
• Receptors, Serotonin (drug effects)