CENU treatment induced bystander effects which are effective on parental and non-parental tumors and have a phospholipid metabolism proton NMR spectroscopy signature.

Abstract

We recently showed, using a parental double B16 melanoma tumor model that, in the presence of CENU-treated primary tumors, untreated secondary tumors exhibited growth inhibition. This response was shown to be related to CENU-induced bystander effects. To see whether CENU-induced bystander effects were still effective on non-parental syngeneic secondary tumors, Lewis lung (3LL) secondary tumors were inoculated in recipients bearing CENU-treated B16 melanoma tumors. Our results show that non-parental secondary 3LL tumors underwent growth inhibition, differentiation, and phospholipid metabolism alterations, all changes similar to those of parental secondary 3LL tumors. This demonstrates the lack of tumor tissue specificity of chemotherapy-induced bystander effects.

• Authors: Patrick Merle, Daniel Morvan, Jean Claude Madelmont, Denis Caillaud, Aicha Demidem
• Journal: International journal of oncology (Int J Oncol) Vol. 29 Issue 3 Pg. 637-42 (Sep 2006) ISSN: 1019-6439 [Print] Greece
• PMID: 16865279 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nitroso Compounds
• Phospholipids
• Protons
• 1-(2-chloroethyl)-1-nitrosourea
• N-(2-chloroethyl)-N-nitrosoacetamide
• Ethylnitrosourea

Topics

• Animals
• Bystander Effect (drug effects)
• Carcinoma, Lewis Lung (drug therapy, metabolism, pathology)
• Cell Differentiation
• Ethylnitrosourea (analogs & derivatives, therapeutic use)
• Lung Neoplasms (drug therapy, metabolism, pathology)
• Magnetic Resonance Spectroscopy
• Melanoma, Experimental (drug therapy, metabolism, pathology)
• Mice
• Mice, Inbred C57BL
• Nitroso Compounds (pharmacology)
• Phospholipids (metabolism)
• Protons