Abstract | BACKGROUND: METHODS: Patients and age-matched controls were recruited from outpatient clinics and a population-based epidemiological survey, respectively. Gln192Arg polymorphism in the PON1 gene was detected by allele-specific PCR technique in 521 patients with AD and 578 healthy controls. RESULTS: The presence of at least one of PON1 R alleles (Q/R or R/R) was lower in AD patients than in the controls (82.7% vs 87.4%; chi(2) = 4.68, P = 0.03). PON1 gene R allele frequency was lower in AD patients than in the controls (60.7% vs 64.7%; chi(2) = 3.85, P = 0.05). One-way ANOVA showed that PON1 genotype had no effect on the age of onset for developing AD. Logistic regression analysis demonstrated the age and sex-adjusted odds ratio (OR) for the risk of AD in PON1 of PON1 R allele carriers was 0.71 (P = 0.044, 95% CI, 0.51 - 0.99). CONCLUSION: Our results indicate that Gln192Arg polymorphism in the PON1 gene is associated with AD, and PON1 R allele might be a protective factor for AD in a Chinese Han ethnic population.
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Authors | Xiao-ming He, Zhen-xin Zhang, Jun-wu Zhang, Yong-tao Zhou, Mou-ni Tang, Cheng-bin Wu, Zhen Hong |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 119
Issue 14
Pg. 1204-9
(Jul 20 2006)
ISSN: 0366-6999 [Print] China |
PMID | 16863614
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aryldialkylphosphatase
- PON1 protein, human
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(genetics)
- Aryldialkylphosphatase
(genetics)
- China
(ethnology)
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
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