[Improvement of thrombocytopenia with normalization of thyroid function in a patient with Graves disease].

Abstract

A 39-year-old man was admitted to our hospital because of hyperthyroidism complicated with fever, atrial fibrillation with rapid ventricular response and congestive heart failure. Laboratory data revealed pancytopenia with a white blood cell count of 3360/microl, Hb 9.6 g/dl, and a platelet count of 88000/ul. After initiation of treatment with 30 mg of thiamazole daily, the patient's thyroid function improved but 4 weeks later, thiamazole induced agranulocytosis occurred and the drug was discontinued. After recovery from agranulocytosis, a subtotal thyroidectomy was performed, and the patient's pancytopenia rapidly improved. In this case, hyperthyroidism itself appeared to be closely related to the development of thrombocytopenia.

• Authors: Akio Okamoto, Kyoko Taniguchi, Yoshihiro Kajita
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 47 Issue 6 Pg. 536-8 (Jun 2006) ISSN: 0485-1439 [Print] Japan
• PMID: 16862983 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• Graves Disease (complications, physiopathology)
• Humans
• Hyperthyroidism (surgery)
• Male
• Thrombocytopenia (complications, physiopathology)
• Thyroid Gland (physiopathology)
• Thyroidectomy (methods)