Perioperative management of a heterozygous carrier of Glanzmann's thrombasthenia submitted to coronary artery bypass grafting with cardiopulmonary bypass.

Abstract

Glanzmann's thrombasthenia is a congenital hemorrhagic disorder transmitted as an autosomal recessive trait and characterized by altered production and/or assembly of the platelet membrane glycoprotein IIb/IIIa receptor. We describe the perioperative management of a heterozygous carrier of Glanzmann's thrombasthenia submitted to cardiac surgery with cardiopulmonary bypass and the case was complicated by early excessive postoperative bleeding.

• Authors: Valter Casati, Armando D'Angelo, Luciano Barbato, Edoardo Rossi, Maria Antonietta Grasso, Salvatore Spagnolo, Ezio Panzeri
• Journal: Anesthesia and analgesia (Anesth Analg) Vol. 103 Issue 2 Pg. 309-11, table of contents (Aug 2006) ISSN: 1526-7598 [Electronic] United States
• PMID: 16861409 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tranexamic Acid

Topics

• Aged
• Cardiopulmonary Bypass
• Coronary Artery Bypass
• Heterozygote
• Humans
• Male
• Postoperative Hemorrhage (etiology)
• Thrombasthenia (complications)
• Tranexamic Acid (therapeutic use)