HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparative immunomodulatory effect of scopoletin on tumoral and normal lymphocytes.

Abstract
Some coumarins possess enhancing effects on lymphocyte mitogen responsiveness. In this investigation, the activity of scopoletin, a coumarin that has been isolated from different plants and in this case specifically from T. cordata Mill., was evaluated. For this purpose, normal T lymphocytes and a hyperproliferative T lymphoma cell line were used. Scopoletin was found to exert a dual action on tumoral lymphocytes exhibiting both a cytostatic and a cytotoxic effect. These effects varied with the concentrations analysed and the time of cell incubation (EC(50): 251+/-15 microg/ml) and were associated to the induction of apoptosis. Scopoletin induced cell proliferation on normal T lymphocytes (Proliferation stimulation index: 1 microg/ml scopoletin: 1.26+/-0.1; 10 microg/ml scopoletin: 3+/-0.25; 100 microg/ml scopoletin: 1.86+/-0.08); this stimulatory action was found to be due to the interaction with kinase C (PKC) protein. These results indicate that scopoletin could be a potential antitumoral compound to be used for cancer treatment.
AuthorsMaría Gabriela Manuele, Graciela Ferraro, Maria Laura Barreiro Arcos, Paula López, Graciela Cremaschi, Claudia Anesini
JournalLife sciences (Life Sci) Vol. 79 Issue 21 Pg. 2043-8 (Oct 19 2006) ISSN: 0024-3205 [Print] Netherlands
PMID16860346 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Immunologic Factors
  • Concanavalin A
  • Scopoletin
Topics
  • Animals
  • Apoptosis (drug effects, immunology)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Cell Survival (drug effects, immunology)
  • Concanavalin A (pharmacology)
  • Dose-Response Relationship, Drug
  • Flowers (chemistry)
  • Immunologic Factors (isolation & purification, pharmacology)
  • Male
  • Mice
  • Mice, Inbred C3H
  • Scopoletin (isolation & purification, pharmacology)
  • T-Lymphocytes (drug effects, immunology)
  • Tilia (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: