Abstract | OBJECTIVE: METHODS: Thirty-six patients with rheumatic heart disease (RHD) were divided into 2 groups randomly: Treatment group (n = 18, given intermittent ventilation once every 5 minutes during CPB; control group ( n = 18), no ventilation during CPB. A brochioalveolar lavage was performed at 2 hours after the CPB. The numbers of granulocytes and the contents of IL-1, IL-6, TNF-alpha, and LDH in the brochioalveolar lavage fluids were measured, and lung PaO2/FiO2 were measured preoperatively and at 1 hour, 4 hours, and 8 hours after the CPB termination. RESULTS: The numbers of granulocytes and the contents of IL-1, IL-6, TNF-alpha, and LDH of the treatment group in the brochioalveolar lavage fluids were significantly lower than those of the control group (P < 0.05), and the lung PaO2/FiO2 of the treatment group at 1 hour, 4 hours, and 8 hours after the CPB termination significantly increased than those of the control group (P < 0.05). A significant decrease of lung PaO2/FiO2 occurred in both groups at 1 hour, 4 hours, and 8 hours after the CPB compared with the same group at the baseline before the CPB (P < 0.01). CONCLUSION: Intermittent ventilation has protective effects on the lung injury during CPB by decreasing granulocyte adhesion and the level of lung cytokines, alleviating the lung inflammatory reaction and endothelial cell injury.
|
Authors | Dian-jun Wang, Bang-liang Yin, Jian-xi Liu, Qing-chun Zhang, Chao Hong, Long-yu Jin |
Journal | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
(Zhong Nan Da Xue Xue Bao Yi Xue Ban)
Vol. 31
Issue 3
Pg. 430-3
(Jun 2006)
ISSN: 1672-7347 [Print] China |
PMID | 16859142
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Cytokines
- Interleukin-1
- Interleukin-6
- Tumor Necrosis Factor-alpha
|
Topics |
- Adult
- Cardiopulmonary Bypass
- Cytokines
(metabolism)
- Female
- Humans
- Interleukin-1
(metabolism)
- Interleukin-6
(metabolism)
- Intermittent Positive-Pressure Breathing
- Lung
(metabolism)
- Male
- Middle Aged
- Rheumatic Heart Disease
(physiopathology, surgery)
- Tumor Necrosis Factor-alpha
(metabolism)
|