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[Influence and significance of intermittent ventilation on lung cytokines during cardiopulmonary bypass].

AbstractOBJECTIVE:
To determine the influence and significance of intermittent ventilation on lung cytokines during cardiopulmonary bypass (CPB).
METHODS:
Thirty-six patients with rheumatic heart disease (RHD) were divided into 2 groups randomly: Treatment group (n = 18, given intermittent ventilation once every 5 minutes during CPB; control group ( n = 18), no ventilation during CPB. A brochioalveolar lavage was performed at 2 hours after the CPB. The numbers of granulocytes and the contents of IL-1, IL-6, TNF-alpha, and LDH in the brochioalveolar lavage fluids were measured, and lung PaO2/FiO2 were measured preoperatively and at 1 hour, 4 hours, and 8 hours after the CPB termination.
RESULTS:
The numbers of granulocytes and the contents of IL-1, IL-6, TNF-alpha, and LDH of the treatment group in the brochioalveolar lavage fluids were significantly lower than those of the control group (P < 0.05), and the lung PaO2/FiO2 of the treatment group at 1 hour, 4 hours, and 8 hours after the CPB termination significantly increased than those of the control group (P < 0.05). A significant decrease of lung PaO2/FiO2 occurred in both groups at 1 hour, 4 hours, and 8 hours after the CPB compared with the same group at the baseline before the CPB (P < 0.01).
CONCLUSION:
Intermittent ventilation has protective effects on the lung injury during CPB by decreasing granulocyte adhesion and the level of lung cytokines, alleviating the lung inflammatory reaction and endothelial cell injury.
AuthorsDian-jun Wang, Bang-liang Yin, Jian-xi Liu, Qing-chun Zhang, Chao Hong, Long-yu Jin
JournalZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 31 Issue 3 Pg. 430-3 (Jun 2006) ISSN: 1672-7347 [Print] China
PMID16859142 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Cytokines
  • Interleukin-1
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
Topics
  • Adult
  • Cardiopulmonary Bypass
  • Cytokines (metabolism)
  • Female
  • Humans
  • Interleukin-1 (metabolism)
  • Interleukin-6 (metabolism)
  • Intermittent Positive-Pressure Breathing
  • Lung (metabolism)
  • Male
  • Middle Aged
  • Rheumatic Heart Disease (physiopathology, surgery)
  • Tumor Necrosis Factor-alpha (metabolism)

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