[Development of testing kits of anti-ganglioside antibody: clinical utility in Guillain-Barré and Fisher syndromes].

Abstract

We developed testing kits for anti-GM1 and anti-GQ1b IgG antibodies and examined their utilities in supporting the diagnosis of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS). Anti-GM1 antibody was detected in 49% of 95 patients with GBS and in 5% or less of disease and normal controls. Anti-GQ1b antibody was detected in 85% of 55 patients with FS, whereas in none of the controls. Eight GBS patients, in whom anti-GM1 IgG antibody was judged negative using the kit, were found to have other anti-ganglioside IgG antibodies. Four of them showed ophthalmoplegia and had anti-GQ1b IgG antibody. Detection of anti-GM1 IgG antibody in GBS and of anti-GQ1b IgG antibody in FS within one week after the disease onset were significantly more frequent compared to albuminocytologic dissociation in the cerebrospinal fluids (GBS, 58% vs 32%; FS, 89% vs 20%). These findings indicate that our testing kits are useful for supporting the early diagnosis of GBS and FS.

• Authors: Mayumi Akiyama, Michiaki Koga, Hiide Yoshino, Akira Hamaoka, Yasuhiko Noguchi, Koichi Hirata, Nobuhiro Yuki
• Journal: No to shinkei = Brain and nerve (No To Shinkei) Vol. 58 Issue 6 Pg. 477-81 (Jun 2006) ISSN: 0006-8969 [Print] Japan
• PMID: 16856515 (Publication Type: English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Gangliosides
• Immunoglobulin G
• Reagent Kits, Diagnostic
• G(M1) Ganglioside
• GQ1b ganglioside

Topics

• Adult
• Autoantibodies (analysis)
• Female
• G(M1) Ganglioside (immunology)
• Gangliosides (immunology)
• Guillain-Barre Syndrome (diagnosis)
• Humans
• Immunoglobulin G (immunology)
• Male
• Middle Aged
• Miller Fisher Syndrome (diagnosis)
• Reagent Kits, Diagnostic (standards)