Intraocular dapiprazole for the reversal of mydriasis after extracapsular cataract extraction with intraocular lens implantation. Part I: Dose-response correlation.

Abstract

Dapiprazole, an alpha-blocking miotic drug, was used intracamerally at the end of extracapsular cataract extraction with posterior chamber intraocular lens (IOL) implantation. The double-blind study included 120 patients divided into four groups of 30 eyes; the groups received balanced salt solution, 0.125%, 0.25%, or 0.5% intraocular dapiprazole after IOL implantation and before suturing. Pupillary diameter recordings were performed immediately before and a few minutes after drug injection and two, four, and eight hours after surgery. The results showed a significant reversal of mydriasis by intraocular dapiprazole, especially with the 0.25% and 0.5% concentrations which did not differ significantly in effectiveness and safety.

• Authors: F Ponte, S Cillino, F Faranda, F Casanova, F Cucci
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 17 Issue 6 Pg. 780-4 (Nov 1991) ISSN: 0886-3350 [Print] United States
• PMID: 1685532 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic alpha-Antagonists
• Piperazines
• Triazoles
• dapiprazole

Topics

• Adrenergic alpha-Antagonists (administration & dosage)
• Adult
• Aged
• Aged, 80 and over
• Anterior Chamber (drug effects)
• Cataract Extraction
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Follow-Up Studies
• Humans
• Lenses, Intraocular
• Male
• Middle Aged
• Piperazines
• Postoperative Care
• Pupil (drug effects)
• Triazoles (administration & dosage)