Inflammatory degeneration of joint tissue in adjuvant arthritis after intraarticular treatment with the mixture of silver drug and nicotinic acid.

Abstract

Combination intraarticular administration of Poviargol (0.5 mg/kg) and nicotinic acid (1.0 mg/kg) reduced symptoms of local and general inflammation in rats with adjuvant arthritis. We revealed a decrease in morphological signs of inflammatory degeneration of joint tissue and reduction of metabolic disorders.

• Authors: V A Mitrofanov, N M Ovchinnikova, S V Belova, M V Fedotova, E V Gladkova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 140 Issue 6 Pg. 702-4 (Dec 2005) ISSN: 0007-4888 [Print] United States
• PMID: 16848229 (Publication Type: Journal Article)

Chemical References

• Glycosaminoglycans
• Silver Compounds
• Uronic Acids
• Vasodilator Agents
• poviargol
• Niacin

Topics

• Animals
• Arthritis, Experimental (pathology)
• Drug Synergism
• Flow Cytometry
• Glycosaminoglycans (metabolism)
• Inflammation (drug therapy)
• Injections, Intra-Articular
• Knee Joint (drug effects, pathology)
• Male
• Niacin (administration & dosage)
• Rats
• Silver Compounds (administration & dosage)
• Synovial Membrane (pathology)
• Uronic Acids (metabolism)
• Vasodilator Agents (administration & dosage)