ENA Actimineral Resource A restores bone loss and bone quality in ovariectomized rats.

Abstract	The purpose of this study was to examine the effects of ENA Actimineral Resource A (ENA-A), seaweed origin alkaline water, on postmenopausal osteoporosis in ovariectomized (OVX) rats. The 12-week old Wistar rats were divided randomly into 4 groups: ovariectomized (OVX), OVX plus 0.5% ENA-A, OVX plus 5% ENA-A and OVX plus 10% ENA-A. A histopathological analysis indicated that ENA-A could prevent OVX-induced bone loss by increasing femur trabecular bone area in a dose-dependent manner. ENA-A significantly (p<0.05) increased serum estradiol levels, decreased serum osteocalcin activity and suppressed serum pyridinoline (PYD) levels. The in vitro effects of ENA-A were also studied using MC3T3-E1 cells. ENA-A significantly stimulated cell proliferation and increased both ALP activity and calcium deposition in a dose-dependent manner. These results suggest that the treatment of ovariectomized rats with ENA-A not only prevents bone resorption but also appears to maintain the cancellous bone structure of postmenopausal osteoporosis.
Authors	Sun Hee Do, Sung-Yong Hwa, Won-Il Jeong, Ji-Won Lee, Hyun-Jung Kim, In-Seon Lee, Kyu-Shik Jeong
Journal	Molecular and cellular biochemistry (Mol Cell Biochem) Vol. 295 Issue 1-2 Pg. 35-43 (Jan 2007) ISSN: 0300-8177 [Print] Netherlands
PMID	16838105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Amino Acids ENA Actimineral Resource A Mineral Waters Minerals Plant Preparations RNA, Messenger Osteocalcin Estradiol pyridinoline Alkaline Phosphatase
Topics	Alkaline Phosphatase (genetics, metabolism) Amino Acids (blood) Animals Body Weight Bone Resorption (therapy) Bone and Bones (cytology, drug effects, pathology) Calcification, Physiologic Cell Differentiation Cell Proliferation Estradiol (blood) Female Gene Expression Regulation, Enzymologic Mineral Waters (therapeutic use) Minerals (therapeutic use) Osteocalcin (blood) Osteoclasts (cytology) Osteogenesis Ovariectomy Plant Preparations (therapeutic use) RNA, Messenger (genetics, metabolism) Rats Rats, Wistar

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!