HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Differences in hippocampal synaptic plasticity in rats with inborn high or low learning ability may be related to different sensitivity of aspartate receptors.

Abstract
Rats with an inborn high (HP) or low (LP) learning capacity were used to study the sensitivity to the blocking effect of 2-amino-phosphonopentanoic acid (AP5; 10 and 20 microM) on long-term potentiation (LTP) produced in hippocampal slices by a 1-s tetanus at 200 Hz. The potential evoked by stimulation of the perforant path was recorded from the granule cell layer of the dentate gyrus in 400 microns slices perfused with standard Krebs' solution or the AP5. Under perfusion with 10 microM of AP5, in 100% of slices from HP rats, LTP generation was not blocked; when AP5 20 microM was used, in 85% of the cases LTP was not blocked. In 60% of slices from LP rats, AP5 10 microM and in 100% of the cases at 20 microM AP5 blocked LTP generation. These results are coherent with the hypothesis that the different inborn learning ability of HP and LP rats is related to the different population or sensitivity of N-methyl-D-aspartate (NMDA) receptors.
AuthorsO A Ramirez, R A Gomez, H F Carrer
JournalBrain research bulletin (Brain Res Bull) Vol. 27 Issue 2 Pg. 291-3 (Aug 1991) ISSN: 0361-9230 [Print] United States
PMID1683809 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Amino Acid
  • Receptors, Cell Surface
  • aspartic acid receptor
  • 2-Amino-5-phosphonovalerate
Topics
  • 2-Amino-5-phosphonovalerate (pharmacology)
  • Animals
  • Electric Stimulation
  • Electrophysiology
  • Granulocytes (physiology)
  • Hippocampus (cytology, physiology)
  • In Vitro Techniques
  • Learning
  • Male
  • Neuronal Plasticity
  • Rats
  • Receptors, Amino Acid
  • Receptors, Cell Surface (physiology)
  • Regression Analysis
  • Synapses (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: