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HIV-specific antibodies but not t-cell responses are associated with protection in seronegative partners of HIV-1-infected individuals in Cambodia.

Abstract
To study biological factors related to protection against HIV-1 infection in Cambodia, we recruited 48 partners of HIV-1-infected patients who remained uninfected (exposed uninfected individuals, EUs) despite unprotected sexual intercourse for more than 1 year and 49 unexposed controls (UCs). HIV-1-specific antibodies (IgA anti-gp41 and IgG anti-CD4-gp120 complex), T-cell responses, and cellular factors that may be involved in protection (peripheral blood mononuclear cell [PBMC] resistance to HIV-1 infection and beta-chemokine production) were evaluated. Anti-HIV-1 antibodies were higher in EUs than those in UCs (P = 0.01 and P = 0.04 for anti-gp41 and anti-CD4-gp120, respectively). We observed a decreased susceptibility to a primary Cambodian isolate, HIV-1KH019, in EU PBMCs as compared with UC PBMCs (P = 0.03). A weak T-cell response to one pool of HIV-1 Gag peptides was found by ELISpot in 1 of 19 EUs. Whereas T-cell specific immunity was not associated to protection, our results suggest that HIV-specific humoral immunity and reduced cell susceptibility to infection may contribute to protection against HIV-1 infection in Cambodian EUs.
AuthorsMarie Nguyen, Polidy Pean, Lucia Lopalco, Janin Nouhin, Viseth Phoung, Nary Ly, Pierre Vermisse, Yvette Henin, Françoise Barré-Sinoussi, Samuele E Burastero, Jean-Marc Reynes, Guislaine Carcelain, Gianfranco Pancino
JournalJournal of acquired immune deficiency syndromes (1999) (J Acquir Immune Defic Syndr) Vol. 42 Issue 4 Pg. 412-9 (Aug 1 2006) ISSN: 1525-4135 [Print] United States
PMID16837821 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HIV Antibodies
Topics
  • Adult
  • Cambodia
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • HIV Antibodies (immunology)
  • HIV Infections (immunology)
  • HIV Seronegativity (immunology)
  • Humans
  • Male
  • Sexual Partners
  • T-Lymphocytes (immunology)

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