Cancer mortality in workers exposed to organochlorine compounds in the pulp and paper industry: an international collaborative study.

Abstract

The objective of this study was to evaluate cancer mortality in pulp and paper industry workers exposed to chlorinated organic compounds. We assembled a multinational cohort of workers employed between 1920 and 1996 in 11 countries. Exposure to both volatile and nonvolatile organochlorine compounds was estimated at the department level using an exposure matrix. We conducted a standardized mortality ratio (SMR) analysis based on age and calendar-period-specific national mortality rates and a Poisson regression analysis. The study population consisted of 60,468 workers. Workers exposed to volatile organochlorines experienced a deficit of all-cause [SMR = 0.91; 95% confidence interval (CI), 0.89-0.93] and all-cancer (SMR = 0.93; 95% CI, 0.89-0.97) mortality, with no evidence of increased risks for any cancer of a priori interest. There was a weak, but statistically significant, trend of increasing risk of all-cancer mortality with increasing weighted cumulative exposure. A similar deficit in all-cause (SMR = 0.94; 95% CI, 0.91-0.96) and all-cancer (SMR = 0.94; 95% CI, 0.89-1.00) mortality was observed in those exposed to nonvolatile organochlorines. No excess risk was observed in cancers of a priori interest, although mortality from Hodgkin disease was elevated (SMR = 1.76; 95% CI, 1.02-2.82) . In this study we found little evidence that exposure to organochlorines at the levels experienced in the pulp and paper industry is associated with an increased risk of cancer, apart from a weak but significant association between all-cancer mortality and weighted cumulative volatile organochlorine exposure.

• Authors: David McLean, Neil Pearce, Hilde Langseth, Paavo Jäppinen, Irena Szadkowska-Stanczyk, Bodil Persson, Pascal Wild, Reiko Kishi, Elsebeth Lynge, Paul Henneberger, Maria Sala, Kay Teschke, Timo Kauppinen, Didier Colin, Manolis Kogevinas, Paolo Boffetta
• Journal: Environmental health perspectives (Environ Health Perspect) Vol. 114 Issue 7 Pg. 1007-12 (Jul 2006) ISSN: 0091-6765 [Print] United States
• PMID: 16835051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydrocarbons, Chlorinated

Topics

• Humans
• Hydrocarbons, Chlorinated (administration & dosage, toxicity)
• Neoplasms (chemically induced, mortality)
• Occupational Diseases (chemically induced, mortality)
• Occupational Exposure
• Paper
• Risk Factors
• Time Factors