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Cardiovascular response to adrenergic stimulation during treatment with tertatolol. A new non-cardioselective beta-blocking agent in primary hypertensive patients.

Abstract
The antihypertensive effects of tertatolol, a new non-cardioselective beta-blocking drug, were investigated in 20 patients with mild to moderate primary arterial hypertension, in a placebo controlled double blind randomized study. After tertatolol 5 mg o.d. significant decreases in both systolic and diastolic blood pressure and in heart rate were observed at rest (BP from 155/103 +/- 3/1 to 139/91 +/- 4/3 mmHg p less than 0.01; HR from 79 +/- 2 to 60 +/- 2 bpm p less than 0.01). Peak blood pressure, heart rate and myocardial O2 consumption, indirectly measured as cardiac workload, determined during adrenergic stimulation by 70 degrees head-up tilt, cold pressor test, mental arithmetic stress, isometric exercise and bicycle exercise were also reduced by 4 weeks of tertatolol treatment in comparison to pretreatment levels. No significant changes in the same parameters were induced by placebo. No side effects were observed during treatment.
AuthorsM L Fasano, I Gaeta, G De Simone, R Iannuzzi, L A Ferrara
JournalJapanese heart journal (Jpn Heart J) Vol. 32 Issue 4 Pg. 435-44 (Jul 1991) ISSN: 0021-4868 [Print] Japan
PMID1683411 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Adrenergic beta-Antagonists
  • Antihypertensive Agents
  • Propanolamines
  • Thiophenes
  • tertatolol
Topics
  • Adolescent
  • Adrenergic beta-Antagonists (pharmacology, therapeutic use)
  • Adult
  • Antihypertensive Agents (pharmacology, therapeutic use)
  • Blood Pressure (drug effects)
  • Double-Blind Method
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (drug therapy, physiopathology)
  • Male
  • Middle Aged
  • Myocardium (metabolism)
  • Oxygen Consumption (drug effects)
  • Propanolamines (pharmacology, therapeutic use)
  • Thiophenes

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