Abstract |
The antihypertensive effects of tertatolol, a new non-cardioselective beta-blocking drug, were investigated in 20 patients with mild to moderate primary arterial hypertension, in a placebo controlled double blind randomized study. After tertatolol 5 mg o.d. significant decreases in both systolic and diastolic blood pressure and in heart rate were observed at rest (BP from 155/103 +/- 3/1 to 139/91 +/- 4/3 mmHg p less than 0.01; HR from 79 +/- 2 to 60 +/- 2 bpm p less than 0.01). Peak blood pressure, heart rate and myocardial O2 consumption, indirectly measured as cardiac workload, determined during adrenergic stimulation by 70 degrees head-up tilt, cold pressor test, mental arithmetic stress, isometric exercise and bicycle exercise were also reduced by 4 weeks of tertatolol treatment in comparison to pretreatment levels. No significant changes in the same parameters were induced by placebo. No side effects were observed during treatment.
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Authors | M L Fasano, I Gaeta, G De Simone, R Iannuzzi, L A Ferrara |
Journal | Japanese heart journal
(Jpn Heart J)
Vol. 32
Issue 4
Pg. 435-44
(Jul 1991)
ISSN: 0021-4868 [Print] Japan |
PMID | 1683411
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic beta-Antagonists
- Antihypertensive Agents
- Propanolamines
- Thiophenes
- tertatolol
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Topics |
- Adolescent
- Adrenergic beta-Antagonists
(pharmacology, therapeutic use)
- Adult
- Antihypertensive Agents
(pharmacology, therapeutic use)
- Blood Pressure
(drug effects)
- Double-Blind Method
- Female
- Heart Rate
(drug effects)
- Humans
- Hypertension
(drug therapy, physiopathology)
- Male
- Middle Aged
- Myocardium
(metabolism)
- Oxygen Consumption
(drug effects)
- Propanolamines
(pharmacology, therapeutic use)
- Thiophenes
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