The use of 16,16-dimethyl-trans-delta 2 prostaglandin E1 methyl ester vaginal suppositories for management of missed abortion and fetal death.

Abstract

The effect of vaginal administration of a PgE1 analogue to terminate missed abortion and fetal death in utero was evaluated in 62 women with gestation ranging from the 13th to the 37th week. Abortion occurred in 85.4% of women with missed abortion and in 86% of women with fetal death. In both groups, the mean induction time was less than 12 h. The incidence of side effects, primarily gastrointestinal symptoms, was infrequent.

• Authors: F Fruzzetti, G B Melis, L De Cecco, A R Genazzani, P Fioretti
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 36 Issue 2 Pg. 115-9 (Oct 1991) ISSN: 0020-7292 [Print] United States
• PMID: 1683312 (Publication Type: Journal Article)

Chemical References

• Prostaglandins E, Synthetic
• 16,16-dimethylprostaglandin E

Topics

• Abortion, Missed (drug therapy)
• Administration, Intravaginal
• Female
• Humans
• Pessaries
• Pregnancy
• Pregnancy Trimester, Second
• Pregnancy Trimester, Third
• Prostaglandins E, Synthetic (administration & dosage, therapeutic use)