Abstract | INTRODUCTION: CLINICAL CASE: We report the first case of a patient with pure alexia secondary to progressive multifocal leukoencephalopathy (PML) as the first manifestation of Human Immunodeficiency Virus ( HIV) infection. Polymerase chain reaction in cerebrospinal fluid was positive for JC virus. Despite favorable immunological and virological response to highly active antiretroviral therapy, neurological symptoms and demyelinating lesions progressed during the first months, and right homonyous hemianopsia, acalculia, and color anomia were noted. In magnetic resonance imaging (MRI) demyelinating lesions involved white matter of both occipital lobes, with left predominance, forceps major and splenium of the corpus callosum, together with white matter of the left temporal lobe and both hippocampal regions. During the following months, coinciding cidofovir treatment, the patient had partial clinical improvement, but neurological deficits persisted. The size of MRI lesions significantly improved. CONCLUSIONS:
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Authors | A M García, I Corral, J Cobo, C Quereda |
Journal | Neurologia (Barcelona, Spain)
(Neurologia)
Vol. 21
Issue 4
Pg. 213-7
(May 2006)
ISSN: 0213-4853 [Print] Spain |
Vernacular Title | Alexia pura secundaria a leucoencefalopatía multifocal progresiva como presentación de la infección por VIH. |
PMID | 16832778
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-HIV Agents
- Organophosphonates
- Cytosine
- Cidofovir
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Topics |
- Alexia, Pure
(diagnosis, etiology)
- Anti-HIV Agents
(therapeutic use)
- Antiretroviral Therapy, Highly Active
- Brain
(pathology)
- Cidofovir
- Cytosine
(analogs & derivatives, therapeutic use)
- HIV Infections
(complications, drug therapy, pathology)
- Humans
- JC Virus
(metabolism)
- Leukoencephalopathy, Progressive Multifocal
(complications, diagnosis, etiology, pathology)
- Magnetic Resonance Imaging
- Organophosphonates
(therapeutic use)
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