A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus.

Abstract

OBJECTIVE:

To compare the effectiveness of cyclosporine solution versus triamcinolone acetonide in orabase in the treatment of oral lichen planus (OLP) in reducing signs and symptoms.

STUDY DESIGN:

One hundred thirty-nine biopsy-proven OLP patients were randomly assigned to cyclosporine (68) or steroid (71) applied onto the target lesion and affected areas. Assessments were at weeks 0, 2, 4, 8 by clinical scoring and grid measurement of the target lesion (reticulation, erythema, ulceration). Patients ranked severity of pain and burning sensation using visual analog scales.

RESULTS:

Although clinical response, pain, burning sensation, area of reticulation, erythema, and ulceration at week 4 were all worse in patients receiving cyclosporine than in those receiving steroid, the differences were not statistically significant. Large patient-to-patient variability was evident over the observation period, with little evidence of marked changes in levels over time in both treatment groups.

CONCLUSION:

Topical cyclosporine appears no more effective than steroid in the treatment of oral lichen planus.

• Authors: Poon Choy Yoke, Goh Bee Tin, Myung-Jin Kim, Annabelle Rajaseharan, Shaheen Ahmed, Kobkan Thongprasom, Mantharop Chaimusik, Shirley Suresh, David Machin, Wong Hwee Bee, Jorgen Seldrup, Asian Lichen Planus Study Group
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 102 Issue 1 Pg. 47-55 (Jul 2006) ISSN: 1528-395X [Electronic] United States
• PMID: 16831672 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Glucocorticoids
• Immunosuppressive Agents
• Orabase
• Cyclosporine
• Triamcinolone Acetonide
• Carboxymethylcellulose Sodium

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Carboxymethylcellulose Sodium (analogs & derivatives)
• Child
• Cyclosporine (therapeutic use)
• Female
• Glucocorticoids (administration & dosage, therapeutic use)
• Humans
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Lichen Planus, Oral (drug therapy)
• Male
• Middle Aged
• Odds Ratio
• Pain Measurement
• Patient Satisfaction
• Regression Analysis
• Treatment Outcome
• Triamcinolone Acetonide (administration & dosage, therapeutic use)