HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238.

Abstract
A new cytotoxic compound, streptokordin, and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isolated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. Biochemical tests and 16S rDNA analysis indicated that the strain belongs to the genus Streptomyces. This actinomycete produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound, designated streptokordin. Its structure was elucidated by FAB-MS, 1H, 13C, and 2D NMR spectroscopy. Streptokordin exhibited significant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria and fungi.
AuthorsSeong-Yun Jeong, Hee Jae Shin, Tae Sik Kim, Hyi-Seung Lee, Song-kyu Park, Hwan Mook Kim
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 59 Issue 4 Pg. 234-40 (Apr 2006) ISSN: 0021-8820 [Print] England
PMID16830891 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibiotics, Antineoplastic
  • DNA, Bacterial
  • DNA, Ribosomal
  • Pyridones
  • RNA, Ribosomal, 16S
  • streptokordin
Topics
  • Antibiotics, Antineoplastic (biosynthesis, chemistry, isolation & purification, pharmacology)
  • Bacteria (drug effects)
  • Cell Line, Tumor
  • Chromatography
  • DNA, Bacterial (chemistry, genetics)
  • DNA, Ribosomal (chemistry, genetics)
  • Drug Screening Assays, Antitumor
  • Fungi (drug effects)
  • Geologic Sediments (microbiology)
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Phylogeny
  • Pyridones (blood, isolation & purification, pharmacology)
  • RNA, Ribosomal, 16S (genetics)
  • Seawater (microbiology)
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Streptomyces (classification, isolation & purification, metabolism)
  • Water Microbiology

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: