Abstract | OBJECTIVE: METHOD: One hundred and forty-four male SD rats were randomly divided into 6 groups (24 rats in each group). Rats in the model control group, positive medicine group, and high, moderate and low curcumin groups were injected with a single dose of bleomycin by trachea, and rats in sham-model control group with same volume normal saline. One day after the injection, curcumin solution of different dosages (200,100,50 mg x kg(-1) x d(-1)) was respectively given to rats in the high, moderate and low curcumin group by daily gastrogavage, while equal volume of normal saline was given to those in the sham-model control group and model control group, and an equal volume of prednisone (0.56 mg x kg(-1) x d(-1)) was saline was given to those in positive medicine control group. On the 7, 14, 28 days, the contents of GSH-Px, SOD, MDA and iNOS in pulmonary tissues of different groups were measured. RESULT:
Curcumin can raise the content of SOD and GSH-Px and lessen the level of MDA and iNOS. CONCLUSION:
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Authors | Gang Zhou, Jian-zhao Niu, Ji-feng Wang, Wei-tao Chen, Tong-xiang Liu, Yin-sheng Li, Zhe-hua Li |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 31
Issue 8
Pg. 669-72
(Apr 2006)
ISSN: 1001-5302 [Print] China |
PMID | 16830828
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Free Radicals
- Bleomycin
- Malondialdehyde
- Glutathione Peroxidase
- Nitric Oxide Synthase Type II
- Superoxide Dismutase
- Curcumin
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Topics |
- Animals
- Antioxidants
(isolation & purification, pharmacology)
- Bleomycin
- Curcuma
(chemistry)
- Curcumin
(isolation & purification, pharmacology)
- Free Radicals
(metabolism)
- Glutathione Peroxidase
(metabolism)
- Lung
(drug effects, metabolism, pathology)
- Male
- Malondialdehyde
(metabolism)
- Nitric Oxide Synthase Type II
(metabolism)
- Plants, Medicinal
(chemistry)
- Pulmonary Fibrosis
(chemically induced, metabolism, prevention & control)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(metabolism)
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