Synthesis of 1-O-monoacyl or 12-O-monoacyl, 1-,12-O-diacyl-, and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity.

1-O-Monoacyl, 12-O-monoacyl, 1-,12-O-diacyl, and 11,12-dehydrated excisanin A 7,14-acetonides were synthesized from excisanin A isolated from Rabdosia excisa. The structure and cytotoxic activity relationships (SAR) of the natural parent ent-kaurene diterpenes and these semisynthetic analogues were studied by using P388 murine leukemia cells.
AuthorsYutaka Aoyagi, Yumi Nishioka, Fukuya Tobe, Tomoyo Hasuda, Koichi Takeya, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 14 Issue 17 Pg. 5802-11 (Sep 1 2006) ISSN: 0968-0896 [Print] England
PMID16828562 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Diterpenes
  • Animals
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology, toxicity)
  • Cell Death (drug effects)
  • Cell Line, Tumor
  • Diterpenes (chemical synthesis, chemistry, pharmacology, toxicity)
  • Mice
  • Molecular Structure
  • Structure-Activity Relationship

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