Synthesis of 1-O-monoacyl or 12-O-monoacyl, 1-,12-O-diacyl-, and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity.

Abstract

1-O-Monoacyl, 12-O-monoacyl, 1-,12-O-diacyl, and 11,12-dehydrated excisanin A 7,14-acetonides were synthesized from excisanin A isolated from Rabdosia excisa. The structure and cytotoxic activity relationships (SAR) of the natural parent ent-kaurene diterpenes and these semisynthetic analogues were studied by using P388 murine leukemia cells.

• Authors: Yutaka Aoyagi, Yumi Nishioka, Fukuya Tobe, Tomoyo Hasuda, Koichi Takeya, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 14 Issue 17 Pg. 5802-11 (Sep 01 2006) ISSN: 0968-0896 [Print] England
• PMID: 16828562 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Diterpenes

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology, toxicity)
• Cell Death (drug effects)
• Cell Line, Tumor
• Diterpenes (chemical synthesis, chemistry, pharmacology, toxicity)
• Mice
• Molecular Structure
• Structure-Activity Relationship