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Factor XII deficiency acquired by orthotopic liver transplantation: case report and review of the literature.

Abstract
Transmission of congenital clotting factor deficiencies after orthotopic liver transplantation is rare. There are published reports of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia, protein S, factor VII and factor XI deficiencies. We report a case of transmission of factor XII deficiency with liver transplantation in a patient with Budd-Chiari syndrome. There was a persistent elevation of the activated partial thromboplastin time (aPTT), but no evidence of bleeding while the patient was maintained on warfarin. The presence of a persistently abnormal aPTT may raise suspicion for the presence of a clotting factor deficiency; however, deficiencies of other clotting factors may not be readily apparent on routine blood tests performed in a donor. Being aware of the possibilities of transmission of these inherited deficiencies of coagulation factors will aid in their early detection and management in the transplant donor and recipient.
AuthorsN K Osborn, Y Ustundag, C S Zent, R H Wiesner, C B Rosen, K V Narayanan Menon
JournalAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 6 Issue 7 Pg. 1743-5 (Jul 2006) ISSN: 1600-6135 [Print] United States
PMID16827880 (Publication Type: Case Reports, Journal Article, Review)
Topics
  • Diagnosis, Differential
  • Factor XII Deficiency (etiology, pathology)
  • Humans
  • Liver Transplantation (adverse effects)
  • Male
  • Middle Aged
  • Partial Thromboplastin Time

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