The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis.

Abstract	JTE-907, N-(benzo[1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxamide, is a selective cannabinoid CB2 receptor antagonist/inverse agonist. The anti-pruritic activity of JTE-907 was studied in NC mice with chronic dermatitis, a model of atopic dermatitis. The oral dose of JTE-907 (1 and 10 mg/kg/day), an immunosuppressant agent tacrolimus (1 mg/kg/day) and a glucocorticoid betamethasone 17-valerate (1 mg/kg/day) for 20 days suppressed the spontaneous scratching and cutaneous nerve activity of NC mice. JTE-907 (10, but not 1, mg/kg) and tacrolimus, but not betamethasone, tended to alleviate the dermatitis. Betamethasone inhibited the body weight gain. These results suggest that JTE-907 suppresses spontaneous itch-associated responses of NC mice without adverse effects such as weight loss.
Authors	Tatsuya Maekawa, Hiroshi Nojima, Yasushi Kuraishi, Kazuo Aisaka
Journal	European journal of pharmacology (Eur J Pharmacol) Vol. 542 Issue 1-3 Pg. 179-83 (Aug 07 2006) ISSN: 0014-2999 [Print] Netherlands
PMID	16824511 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Dioxoles Glucocorticoids Immunosuppressive Agents JTE 907 Quinolones Receptor, Cannabinoid, CB2 Betamethasone Valerate Tacrolimus
Topics	Administration, Oral Animals Behavior, Animal (drug effects) Betamethasone Valerate (administration & dosage, pharmacology) Body Weight (drug effects) Dermatitis, Atopic (pathology, physiopathology, prevention & control) Dioxoles (administration & dosage, pharmacology) Disease Models, Animal Dose-Response Relationship, Drug Glucocorticoids (administration & dosage, pharmacology) Immunosuppressive Agents (administration & dosage, pharmacology) Male Mice Mice, Inbred Strains Pruritus (pathology, physiopathology, prevention & control) Quinolones (administration & dosage, pharmacology) Receptor, Cannabinoid, CB2 (agonists) Severity of Illness Index Skin (drug effects, innervation, pathology) Tacrolimus (administration & dosage, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!