[Ziprasidone as coadjuvant treatment in resistant obsessive-compulsive disorder treatment].

Abstract

Data suggest that atypical antipsychotics may be useful in the treatment of obsessive-compulsive disorder (OCD). We report the case of a patient diagnosed of serious OCD resistant to various antidepressant and antipsychotic treatments (including clozapine). The patient had clinically significant improvement (measured by decrease in the score of the Yale-Brown Obsessive Compulsive (Y-BOCS) and the Clinical Global Impression (CGI) scales) in the four weeks alter switching from clozapine to ziprasidone, improvement that was subsequently maintained. The pharmacodynamic characteristics of ziprasidone could make this drug more effective than other antipsychotics as coadjuvant treatment in OCD

• Authors: C Iglesias Garcia, S Santamarina Montila, M J Alonso Villa
• Journal: Actas espanolas de psiquiatria (Actas Esp Psiquiatr) 2006 Jul-Aug Vol. 34 Issue 4 Pg. 277-9 ISSN: 1139-9287 [Print] Spain
• Vernacular Title: La ziprasidona como tratamiento co adyuvante en el tratamiento del trastorno obsesivo-compulsivo resistente.
• PMID: 16823689 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antipsychotic Agents
• Cyclohexanols
• Piperazines
• Thiazoles
• ziprasidone
• Venlafaxine Hydrochloride

Topics

• Antipsychotic Agents (metabolism, therapeutic use)
• Cyclohexanols (metabolism, therapeutic use)
• Drug Resistance
• Drug Synergism
• Drug Therapy, Combination
• Female
• Humans
• Middle Aged
• Obsessive-Compulsive Disorder (diagnosis, drug therapy, psychology)
• Piperazines (pharmacology, therapeutic use)
• Severity of Illness Index
• Thiazoles (pharmacology, therapeutic use)
• Venlafaxine Hydrochloride