Mcm-2 protein expression predicts prognosis better than Ki-67 antigen in oral cavity squamocellular carcinoma.

Abstract

BACKGROUND:

The present study aimed at evaluating the expression intensities of the Mcm-2 protein and Ki-67 antigen in squamocellular carcinomas of the oral cavity and comparing their prognostic value.

MATERIALS AND METHODS:

Forty-nine patients, operated on and treated with radiotherapy for carcinoma of the oral cavity floor and/or the mobile part of the tongue, were retrospectively analyzed.

RESULTS:

A significant positive correlation was noted between the expression of Mcm-2 protein and that of the Ki-67 antigen, as well as an absence of such correlations with the remaining examined factors. A significant correlation with worse disease-specific survival period (DSS) in the group of patients demonstrating Mcm-2 protein expression in over 10% of cancer cells was detected (5-year cumulative DSS 50% vs. 76%).

CONCLUSION:

The results suggested that the expression of Mcm-2 protein may be used as a prognostic factor in patients with squamocellular carcinoma of the oral cavity.

• Authors: Jolanta Szelachowska, Piotr Dziegiel, Joanna Jelen-Krzeszewska, Michal Jelen, Rafal Matkowski, Agnieszka Pomiecko, Barbara Spytkowska, Maria Jagas, Iwona Gisterek, Jan Kornafel
• Journal: Anticancer research (Anticancer Res) 2006 May-Jun Vol. 26 Issue 3B Pg. 2473-8 ISSN: 0250-7005 [Print] Greece
• PMID: 16821635 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cell Cycle Proteins
• Ki-67 Antigen
• Nuclear Proteins
• MCM2 protein, human
• Minichromosome Maintenance Complex Component 2

Topics

• Carcinoma, Squamous Cell (metabolism, pathology, radiotherapy, surgery)
• Cell Cycle Proteins (biosynthesis)
• Disease-Free Survival
• Female
• Humans
• Immunohistochemistry
• Ki-67 Antigen (biosynthesis)
• Male
• Middle Aged
• Minichromosome Maintenance Complex Component 2
• Mouth Neoplasms (metabolism, pathology, radiotherapy, surgery)
• Nuclear Proteins (biosynthesis)
• Predictive Value of Tests
• Retrospective Studies