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A norbergenin derivative inhibits neuronal cell damage induced by tunicamycin.

Abstract
Several chemically synthesized compounds were examined for protective effects against the cell damage in tunicamycin-treated human neuroblastoma IMR-32 cells. Among the compounds tested, an antioxidant, Norbergenin-11-caproate (10 microM), exhibited complete protection against the cell growth inhibitory effect of tunicamycin but did not inhibit the induction of Bip/GRP78 mRNA by tunicamycin. Both norbergenin-11-caproate and alpha-tocopherol completely inhibited the production of reactive oxygen species induced by tunicamycin, however, alpha-tocopherol inhibited tunicamycin-induced cell damage only partially, even at 100 microM. These findings suggest the potential of Norbergenin-11-caproate for therapeutic application in endoplasmic reticulum (ER) stress-dependent diseases implicating a specific mechanism other than anti-oxidative one.
AuthorsShinya Suzuki, Yui Okuse, Masafumi Kawase, Masufumi Takiguchi, Yoshiyasu Fukuyama, Hironobu Takahashi, Masao Sato
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 29 Issue 7 Pg. 1335-8 (Jul 2006) ISSN: 0918-6158 [Print] Japan
PMID16819164 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzopyrans
  • DNA Primers
  • Drugs, Chinese Herbal
  • Endoplasmic Reticulum Chaperone BiP
  • HSPA5 protein, human
  • Heat-Shock Proteins
  • Molecular Chaperones
  • Reactive Oxygen Species
  • Tunicamycin
  • norbergenin
Topics
  • Benzopyrans (pharmacology)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • DNA Primers
  • Drugs, Chinese Herbal
  • Endoplasmic Reticulum Chaperone BiP
  • Flow Cytometry
  • Heat-Shock Proteins (genetics)
  • Humans
  • Japan
  • Molecular Chaperones (genetics)
  • Neuroblastoma
  • Reactive Oxygen Species (metabolism)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tunicamycin (toxicity)

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