Granulocyte and monocyte adsorption apheresis for cutaneous allergic vasculitis.

Abstract

Cutaneous allergic vasculitis (CAV) is characterized clinically by purpuric patches with secondary ulcerations, and histologically by leukocytoclastic vasculitis with neutrophil infiltrates. Granulocyte and monocyte adsorption apheresis (GCAP) is an extracorporeal apheresis instrument using a column containing cellulose acetate beads designed to remove pathogenic granulocytes. Here we report our assessment of the efficacy of GCAP for recurrent leg ulcers in a 49-year-old woman with CAV. She underwent five GCAP treatments at one-week intervals. In each treatment session, 1800 mL of blood was processed. Her leg ulcers responded well and her white blood cell and neutrophil counts and the expression level of CD11b/CD18, a marker for activated neutrophils, on her peripheral neutrophils were reduced from 7500/microL to 6500/microL, 4350/microL to 3315/microL, and 64.9 MFI (mean fluorescence intensity) to 27.0 MFI (normal controls: 10.5 +/- 1.2 MFI) by GCAP, respectively. These results suggest that GCAP is useful for skin disorders with leucocytoclastic vasculitis.

• Authors: Takuro Kanekura, Noriko Yoshii, Koichi Kawahara, Ikuro Maruyama, Tamotsu Kanzaki
• Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 10 Issue 3 Pg. 287-90 (Jun 2006) ISSN: 1744-9979 [Print] Australia
• PMID: 16817796 (Publication Type: Case Reports, Journal Article)

Chemical References

• Macrophage-1 Antigen

Topics

• Blood Component Removal (methods)
• Female
• Hemoperfusion (methods)
• Humans
• Macrophage-1 Antigen (blood, metabolism)
• Middle Aged
• Monocytes (immunology)
• Neutrophils (immunology)
• Treatment Outcome
• Vasculitis, Leukocytoclastic, Cutaneous (therapy)