Abstract |
We have retrospectively compared the effectiveness of five different regimens for inducing and maintaining clinical remission in 206 patients with idiopathic proctitis (n = 115) and proctosigmoiditis (n = 91). The five therapeutic regimens were: corticosteroid enemas, 5-aminosalicylic acid (5-ASA) enemas, oral 5-ASA ( sulfasalazine or mesalamine), corticosteroid enemas plus oral 5-ASA, or 5-ASA enemas plus oral 5-ASA. Clinical remission was achieved within 28 days of therapy in 47%, and eventually in 94% of these patients. No significant differences in efficacy were found among the five regimens. Most patients ultimately experienced a recurrence of symptoms, but the duration of remission was significantly longer with maintenance oral sulfasalazine or mesalamine (17.2 months) than with no therapy (11.8 months), P less than 0.01. We conclude that several regimens are equally effective in inducing remission of proctitis and proctosigmoiditis, although prolonged therapy may be needed to accomplish this goal. Maintenance oral 5-ASA significantly prolongs symptomatic remission in proctitis and proctosigmoiditis.
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Authors | D LaRosa, P H Rubin, C Bodian, D H Present |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 86
Issue 10
Pg. 1456-60
(Oct 1991)
ISSN: 0002-9270 [Print] United States |
PMID | 1681725
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Colitis, Ulcerative
(drug therapy, prevention & control)
- Female
- Humans
- Male
- Middle Aged
- Proctitis
(drug therapy)
- Recurrence
- Remission Induction
- Retrospective Studies
- Sulfasalazine
(administration & dosage)
- Time Factors
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