Is mPGES-1 a promising target for pain therapy?

Abstract

Cyclooxygenase (COX) inhibitors are widely used analgesic and anti-inflammatory drugs. Owing to undesirable effects caused by unselective COX inhibitors and selective COX-2 inhibitors, microsomal prostaglandin E(2) synthase-1 has been considered as an alternative target for the development of analgesic drugs. However, recent findings question the usefulness of this terminal synthase as a promising drug target for pain therapy.

• Authors: Klaus Scholich, Gerd Geisslinger
• Journal: Trends in pharmacological sciences (Trends Pharmacol Sci) Vol. 27 Issue 8 Pg. 399-401 (Aug 2006) ISSN: 0165-6147 [Print] England
• PMID: 16815559 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cyclooxygenase Inhibitors
• Intramolecular Oxidoreductases
• PTGES protein, human
• Prostaglandin-E Synthases

Topics

• Animals
• Cyclooxygenase Inhibitors (pharmacology, therapeutic use)
• Humans
• Intramolecular Oxidoreductases (antagonists & inhibitors, metabolism)
• Models, Biological
• Pain (drug therapy, enzymology)
• Prostaglandin-E Synthases