Abstract | PURPOSE OF REVIEW: RECENT FINDINGS:
Alvimopan exerts mixed, but generally favorable, effects on restoration of gastrointestinal motility in patients with postoperative ileus. The observation of increased opioid requirements (without increased pain scores) and associated clinical ramifications requires further study. Tegaserod stimulates the peristaltic reflex and improves motility in multiple sites along the gastrointestinal tract. Its efficacy in improving gastrointestinal hypomotility in the critically ill population has not yet been determined. Furthermore, its use has been associated with the development of ischemic colitis and increased requirement for abdominal/pelvic surgery. Dexloxiglumide may be beneficial for improving gastric emptying in critically ill patients, especially those receiving lipid-enriched enteral feeds. SUMMARY: Novel prokinetic agents show promise for management of gastrointestinal hypomotility in the critically ill population. However, further study is required before these agents can be recommended for use.
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Authors | Derek J Roberts, Hoan Linh Banh, Richard I Hall |
Journal | Current opinion in critical care
(Curr Opin Crit Care)
Vol. 12
Issue 4
Pg. 295-302
(Aug 2006)
ISSN: 1070-5295 [Print] United States |
PMID | 16810038
(Publication Type: Journal Article, Review)
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Chemical References |
- Gastrointestinal Agents
- Indoles
- Pentanoic Acids
- Piperidines
- tegaserod
- alvimopan
- dexloxiglumide
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Topics |
- Adult
- Critical Illness
- Gastrointestinal Agents
(pharmacology)
- Gastrointestinal Motility
(drug effects)
- Humans
- Indoles
(pharmacology)
- Pentanoic Acids
(pharmacology)
- Piperidines
(pharmacology)
|