| Abstract | OBJECTIVES: In this study we examined the anti-Helicobacter pylori (anti-H. pylori) antibodies in patients with autoimmune thyroiditis, with and without different polyglandular involvement, and in healthy controls. MATERIAL & METHODS: Patients with autoimmune thyroiditis (AT) were divided into three groups: Group A: 23 patients with isolated AT, Group B: 30 patients with AT as a part of polyglandular activation of autoimmunity, and Group C: 7 patients with AT as a part of autoimmune polyglandular syndrome type II. Thirty healthy individuals served as controls (Group D). Anti-H. pylori antibodies were determined first by ELISA for classes IgG, IgA, and IgM, and subsequently by immunoblot for classes IgG and IgA. RESULTS: ELISA: The number of patients with IgA antibodies in Group A (39%) and Group B (30%) differed significantly from controls (7%, p<0.05). Immunoblot: Anti-CagA antibodies were found in 13% of patients in Group A, 7% of Group B, 0% of Group C, and 20% of Group D. A higher seroprevalence, as compared to controls, was found for IgG to the VacA (p=0.01), 30 kDa (p=0.001), and 17 kDa (p=0.008) antigens in Group A and for IgG to the 30 kDa antigen in Group C (p=0.037). A significantly higher seroprevalence, as compared to controls, was likewise found for IgA to the 17 kDa antigen in Group A (p=0.015). CONCLUSIONS: A different distribution of antibodies to H. pylori antigens was found in patients with isolated AT compared to patients with AT coupled with a polyglandular syndrome. |
| Authors | Ivan Sterzl, Pavlina Hrda, Bela Potuznikova, Petr Matucha, Vaclav Hana, Vaclav Zamrazil
(Affiliation: Institute of Immunology and Microbiology, 1st Medical Faculty, Charles University, General Faculty Hospital, Prague, Czech Republic. ister at lf1.cuni.cz)
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| Journal | Neuro endocrinology letters
(Neuro Endocrinol Lett)
Vol. 27 Suppl 1
Pg. 41-5
(Dec 2006)
ISSN: 0172-780X Sweden |
| PMID | 16804516
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antibodies, Bacterial
- Immunoglobulin A
|
| Topics |
- Adult
- Antibodies, Bacterial
(analysis)
- Case-Control Studies
- Female
- Helicobacter Infections
(complications, immunology)
- Helicobacter pylori
(immunology, pathogenicity)
- Humans
- Immunoglobulin A
(analysis)
- Male
- Middle Aged
- Thyroiditis, Autoimmune
(immunology, microbiology, pathology)
|
