Abstract |
The previously unknown coronavirus that caused severe acute respiratory syndrome (SARS-CoV) affected more than 8,000 persons worldwide and was responsible for more than 700 deaths during the first outbreak in 2002-2003. For reasons unknown, the SARS virus is less severe and the clinical progression a great deal milder in children younger than 12 years of age. In contrast, the mortality rate can exceed 50% for persons at or above the age of 60. As part of the Sino-European Project on SARS Diagnostics and Antivirals (SEPSDA), an immune phage-display library is being created from convalescent patients in a phagemid system for the selection of single-chain fragment variables ( scFv) antibodies recognizing the SARS-CoV.
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Authors | Morten Draeby Sørensen, Brian Sørensen, Regina Gonzalez-Dosal, Connie Jenning Melchjorsen, Jens Weibel, Jing Wang, Chen Wie Jun, Yang Huanming, Peter Kristensen |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 1067
Pg. 500-5
(May 2006)
ISSN: 0077-8923 [Print] United States |
PMID | 16804033
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antibodies, Viral
- Antiviral Agents
- Immunoglobulin Fragments
- Peptide Library
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Topics |
- Antibodies, Viral
(immunology)
- Antiviral Agents
(immunology, therapeutic use)
- Enzyme-Linked Immunosorbent Assay
- Fluorescent Antibody Technique, Indirect
- Humans
- Immunoglobulin Fragments
(immunology)
- Peptide Library
- Severe acute respiratory syndrome-related coronavirus
(genetics, immunology, isolation & purification)
- Serology
- Severe Acute Respiratory Syndrome
(diagnosis, immunology, therapy, virology)
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