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Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals.

Abstract
The previously unknown coronavirus that caused severe acute respiratory syndrome (SARS-CoV) affected more than 8,000 persons worldwide and was responsible for more than 700 deaths during the first outbreak in 2002-2003. For reasons unknown, the SARS virus is less severe and the clinical progression a great deal milder in children younger than 12 years of age. In contrast, the mortality rate can exceed 50% for persons at or above the age of 60. As part of the Sino-European Project on SARS Diagnostics and Antivirals (SEPSDA), an immune phage-display library is being created from convalescent patients in a phagemid system for the selection of single-chain fragment variables (scFv) antibodies recognizing the SARS-CoV.
AuthorsMorten Draeby Sørensen, Brian Sørensen, Regina Gonzalez-Dosal, Connie Jenning Melchjorsen, Jens Weibel, Jing Wang, Chen Wie Jun, Yang Huanming, Peter Kristensen
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1067 Pg. 500-5 (May 2006) ISSN: 0077-8923 [Print] United States
PMID16804033 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antibodies, Viral
  • Antiviral Agents
  • Immunoglobulin Fragments
  • Peptide Library
Topics
  • Antibodies, Viral (immunology)
  • Antiviral Agents (immunology, therapeutic use)
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Immunoglobulin Fragments (immunology)
  • Peptide Library
  • Severe acute respiratory syndrome-related coronavirus (genetics, immunology, isolation & purification)
  • Serology
  • Severe Acute Respiratory Syndrome (diagnosis, immunology, therapy, virology)

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