Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: During levosimendan infusion an increase in cardiac index (30% after 6 h and 24 h), a decrease in heart rate (4% after 6 h and 10% after 24 h, respectively), and a decrease in systemic vascular resistance (27% after 6 h and 41% after 24 h, respectively) appeared. In combination with volume resuscitation the pulmonary capillary wedge pressure increased. Under therapy with levosimendan no relevant adverse events occurred; there was no increase in severe cardiac arrhythmias and QT interval duration. CONCLUSION:
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Authors | Karin Müller, Ansgar Peters, Tobias Zeus, Markus Hennersdorf, Bodo Eckehard Strauer |
Journal | Medizinische Klinik (Munich, Germany : 1983)
(Med Klin (Munich))
Vol. 101 Suppl 1
Pg. 119-22
(Mar 22 2006)
ISSN: 0723-5003 [Print] Germany |
Vernacular Title | Akute hämodynamische und klinische Effekte von Levosimendan in der Therapie des kardiogenen Schocks. |
PMID | 16802535
(Publication Type: Journal Article)
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Chemical References |
- Calcium Channel Agonists
- Cardiotonic Agents
- Hydrazones
- Pyridazines
- Simendan
- Dobutamine
- Norepinephrine
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Topics |
- Adult
- Aged
- Calcium Channel Agonists
(administration & dosage, adverse effects)
- Cardiotonic Agents
(administration & dosage, adverse effects)
- Conscious Sedation
- Critical Care
- Dobutamine
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Therapy, Combination
- Electrocardiography
(drug effects)
- Female
- Heart Failure
(drug therapy)
- Hemodynamics
(drug effects)
- Humans
- Hydrazones
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Norepinephrine
(administration & dosage, adverse effects)
- Pyridazines
(administration & dosage, adverse effects)
- Shock, Cardiogenic
(drug therapy)
- Simendan
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