Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study.

Abstract

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

• Authors: Hilary A Archer, Paul Edison, David J Brooks, Jo Barnes, Chris Frost, Tom Yeatman, Nick C Fox, Martin N Rossor
• Journal: Annals of neurology (Ann Neurol) Vol. 60 Issue 1 Pg. 145-7 (Jul 2006) ISSN: 0364-5134 [Print] United States
• PMID: 16802294 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
• Amyloid
• Aniline Compounds
• Carbon Radioisotopes
• Thiazoles

Topics

• Aged
• Alzheimer Disease (diagnostic imaging, metabolism, pathology)
• Amyloid (metabolism)
• Aniline Compounds
• Atrophy
• Brain (diagnostic imaging, metabolism, pathology)
• Carbon Radioisotopes
• Cohort Studies
• Female
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Positron-Emission Tomography (methods)
• Thiazoles