Abstract |
Platelet factor-3 ( PF(3)) availability and platelet aggregation to ADP (4 micromol/l) and adrenaline (1.2 micromol/l) were evaluated in patients being treated with 5-fluorouracil (5-FU) for gastrointestinal malignancy. It produced a significant reduction in platelet aggregation and platelet factor-3 ( PF(3)) availability ( P < 0.001) without being associated with thrombocytopenia. The changes in platelet aggregation occurred during the first week of chemotherapy and continued with subsequent courses. This acquired abnormality may be responsible for a haemorrhagic diathesis even without obvious thrombocytopenia. Study of platelet function is important and may be considered to assess the haematological toxicity in patients being treated with systemic 5-FU therapy.
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Authors | A Kumar, R Kumar, A Sandilium, J Shukla, S Pradhan |
Journal | Platelets
(Platelets)
Vol. 10
Issue 2-3
Pg. 137-40
( 1999)
ISSN: 0953-7104 [Print] England |
PMID | 16801083
(Publication Type: Journal Article)
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