Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin A.

Abstract

OBJECTIVE:

To explore the therapy to further elevate the efficacy of the treatment of chronic aplastic anemia (CAA).

METHODS:

Forty-five patients with CCA were assigned into two groups, the 26 patients in the treated group were treated by Shengxuening (a Chinese herbal preparation) and cyclosporin A (CsA), and the 19 patients in the control group were treated with androgen alone, with the therapeutic course lasting for over 3 months. Changes of peripheral blood picture, and the colony productivity of burst forming unit-erythroid (BFU-E), colony forming unit-erythroid (CFU-E) and colony forming unit-granulocyte macrophage (CFU-GM) in bone marrow were observed before and after 3 months treatment. The amount of erythrocyte and platelet infusion, frequency of infection, condition of hemorrhage and relevant death were also observed. The follow-up study was conducted for over half a year.

RESULTS:

The total effective rate in the treated group was 84.6%, which was significantly higher than that in the control group (52.6%, P < 0.05). Levels of hemoglobin, reticulocyte, neutrophil and platelet increased after treatment in the treated group, as compared with those before treatment, with significant difference (P < 0.05), and the colony productivity of BFU-E, CFU-E and CFU-GM in bone marrow also got significantly increased (P < 0.01), and showed significant difference from those in the control group (P < 0.05).

CONCLUSION:

Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA.

• Authors: Xue-zhong Zhang, Yan-li Xu, Juan Jin, Xiu-qun Zhang, Lei Zhang, Ai-ling Su
• Journal: Chinese journal of integrative medicine (Chin J Integr Med) Vol. 12 Issue 2 Pg. 142-5 (Jun 2006) ISSN: 1672-0415 [Print] China
• PMID: 16800995 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Androgens
• Drugs, Chinese Herbal
• Hemoglobins
• Tablets
• shengxuening
• Stanozolol
• Cyclosporine

Topics

• Adult
• Aged
• Androgens (therapeutic use)
• Anemia, Aplastic (drug therapy)
• Chronic Disease
• Cyclosporine (administration & dosage)
• Drugs, Chinese Herbal (administration & dosage)
• Erythroid Precursor Cells
• Follow-Up Studies
• Hemoglobins (analysis)
• Humans
• Medicine, Chinese Traditional
• Middle Aged
• Neutrophils (cytology)
• Platelet Count
• Reticulocytes (cytology)
• Stanozolol (therapeutic use)
• Tablets