Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer.

Abstract

OBJECTIVE:

To investigate the effect of Chinese recipe, Wuye Decoction (WYD), on immune function in patients with non-small cell lung cancer (NSCLC).

METHODS:

Eighty-two patients of NSCLC with pathologically confirmed diagnosis, who had received operative treatment and completed the post-operational chemotherapy, were randomly assigned into 2 groups. Group A (42 cases) received WYD and Group B (40 cases) received no specific medicine. Positive rate of various peripheral lymphocyte subsets, including CD3, CD4, CD8, CD16, CD19 and CD25, in both groups was observed immediately after chemotherapy (T(0)) and 3 months later (T(1)), the same indexes of 20 healthy volunteers allocated in Group C were also determined at T(0) for control.

RESULTS:

The positive rates of CD4, CD4/CD8, CD16, CD19 and CD25 were significantly lower (P < 0.05) while that of CD8 was significantly higher (P < 0.05) in Group A and B at T(0) than those in Group C; at T(1), these indexes, except CD25, got significantly restored in Group A with the level approaching normal range (P > 0.05), and showed significant difference from those in Group B (P < 0.05), since these indexes in that group remained unchanged at the corresponding period. As for CD25, it was insignificantly changed in Group A after WYD treatment, and thus, at T(1), it was still lower than that in Group C (P < 0.05) and showed insignificant difference as compared with that in Group B (P > 0.05). Comparison of CD3 among the 3 groups showed no significant difference (P > 0.05).

CONCLUSION:

WYD could activate the immune function of NSCLC patients, and so it is recommended to be used in the treatment of NSCLC in clinical practice.

• Authors: Shun-li Zheng, Qing-sheng Yang, Xiao-hong Ma
• Journal: Chinese journal of integrative medicine (Chin J Integr Med) Vol. 12 Issue 2 Pg. 118-21 (Jun 2006) ISSN: 1672-0415 [Print] China
• PMID: 16800990 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Adjuvants, Immunologic
• Drugs, Chinese Herbal
• wuye decoction

Topics

• Adjuvants, Immunologic (pharmacology, therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy, immunology)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Female
• Humans
• Lung Neoplasms (drug therapy, immunology)
• Lymphocyte Subsets (immunology)
• Male
• Middle Aged
• Phenotype