Abstract |
The short-term additive effect and side effects of adding 1% apraclonidine hydrochloride to nonselective beta-blockers were investigated in 21 patients with ocular hypertension or early primary open-angle glaucoma. After a unilateral single dose application of topical 1% apraclonidine hydrochloride, intraocular pressure (IOP), heart rate, and interpalpebral distance were measured. The mean IOP of treated eyes showed a decline from a baseline of 20.0 +/- 3.0 mmHg to 18.1 +/- 3.2 mmHg at 1 hour (P less than 0.005), 16.5 +/- 2.6 mmHg at 2 hours (P less than 0.001), 15.2 +/- 2.5 mmHg at 3 hours (P less than 0.001), 18.5 +/- 3.0 mmHg at 12 hours (P = 0.02), and 19.2 +/- 2.9 mmHg at 24 hours (P = 0.2). No statistically significant change in the heart rate was seen. The interpalpebral distance of the treated eyes showed a significant increase (P less than 0.05) at all time intervals except 24 hours (P = 0.17). The authors conclude that 1% apraclonidine hydrochloride provides an additive pressure-lowering effect to nonselective beta-blockers for at least 12 hours after a single application, and shows promise as a useful adjunctive agent for short-term use in glaucoma therapy.
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Authors | M K Yaldo, D H Shin, K A Parrow, S H Lee, S Y Lee |
Journal | Ophthalmology
(Ophthalmology)
Vol. 98
Issue 7
Pg. 1075-8
(Jul 1991)
ISSN: 0161-6420 [Print] United States |
PMID | 1679916
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic alpha-Agonists
- Timolol
- apraclonidine
- Levobunolol
- Clonidine
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Topics |
- Adrenergic alpha-Agonists
(therapeutic use)
- Clonidine
(analogs & derivatives, therapeutic use)
- Double-Blind Method
- Drug Synergism
- Female
- Glaucoma, Open-Angle
(drug therapy)
- Heart Rate
(drug effects)
- Humans
- Intraocular Pressure
(drug effects)
- Levobunolol
(therapeutic use)
- Male
- Ocular Hypertension
(drug therapy)
- Prospective Studies
- Random Allocation
- Timolol
(therapeutic use)
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