Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: Median citrulline concentrations were significantly higher in the citrulline group versus the placebo group immediately postoperatively (36 micromol/L vs 26 micromol/L, P = .012) and at 12 hours postoperatively (37 micromol/L vs 20 micromol/L, P = .015). Mean plasma arginine concentrations were significantly higher in the citrulline group versus the placebo group by 12 hours postoperatively (36 micromol/L vs 23 micromol/L, P = .037). Mean systemic blood pressure did not differ between groups (P = .53). Postoperative pulmonary hypertension developed in 9 patients, 6 of 20 (30%) in the placebo group and 3 of 20 (15%) in the citrulline group (P = .451), all of whom had plasma citrulline concentrations less than age-specific norms. Postoperative pulmonary hypertension did not develop in patients who demonstrated plasma citrulline concentrations in excess of 37 mumol/L (P = .036). CONCLUSIONS:
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Authors | Heidi A B Smith, Jeffrey A Canter, Karla G Christian, Davis C Drinkwater, Frank G Scholl, Brian W Christman, Geraldine D Rice, Frederick E Barr, Marshall L Summar |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 132
Issue 1
Pg. 58-65
(Jul 2006)
ISSN: 1097-685X [Electronic] United States |
PMID | 16798303
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Administration, Oral
- Arginine
(blood)
- Blood Pressure
- Cardiac Surgical Procedures
(adverse effects)
- Child, Preschool
- Citrulline
(administration & dosage, blood, therapeutic use)
- Double-Blind Method
- Female
- Fontan Procedure
- Humans
- Hypertension, Pulmonary
(prevention & control)
- Infant
- Male
- Multivariate Analysis
- Pilot Projects
- Postoperative Complications
(prevention & control)
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