Abstract |
Although several advances have occurred concerning the use of electroconvulsive therapy, little progress has been made in understanding the mechanisms underlying its therapeutic or side effects. Na(+),K(+)- ATPase is an important enzyme of central nervous system, responsible for ionic gradient maintenance and consumption of approximately 40-50% of brain ATP. This work was performed in order to determine Na(+),K(+)- ATPase activity after acute and chronic electroconvulsive shock. Results showed an inhibition of Na(+),K(+)- ATPase activity in the hippocampus 48 h, 7, 30, 60 and 90 days after a single electroconvulsive shock. Chronic treatment diminished the enzyme activity in the hippocampus 7 and 30 days after electroconvulsive (ECS) sessions. Our findings demonstrated that Na(+),K(+)- ATPase activity is altered by ECS.
|
Authors | Emilio L Streck, Gustavo Feier, Márcio Búrigo, Renata Franzon, Felipe Dal-Pizzol, João Quevedo, Angela T S Wyse |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 404
Issue 3
Pg. 254-7
(Sep 01 2006)
ISSN: 0304-3940 [Print] Ireland |
PMID | 16797841
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Sodium-Potassium-Exchanging ATPase
|
Topics |
- Animals
- Electroconvulsive Therapy
(adverse effects)
- Hippocampus
(enzymology)
- Male
- Rats
- Rats, Wistar
- Sodium-Potassium-Exchanging ATPase
(metabolism)
|