Photodynamic cell-kill analysis of breast tumor cells with a tamoxifen-pyropheophorbide conjugate.

Abstract

We hypothesized that estrogen receptor (ER) in hormone-sensitive breast cancer cells could be targeted for selective photodynamic killing of tumor cell with antiestrogen-porphyrin conjugates by combining the over-expression of ER in hormone-sensitive breast cancer cells and tumor-retention property of porphyrin photosensitizers. In this study we describe that a tamoxifen (TAM)-pyropheophorbide conjugate that specifically binds to ER alpha, caused selective cell-kill in MCF-7 breast cancer cells upon light exposure. Therefore, it is a potential candidate for ER-targeted photodynamic therapy of cancers (PDT) of tissues and organs that respond to estrogens/antiestrogens.

• Authors: Ana Fernandez Gacio, Carlos Fernandez-Marcos, Narasimha Swamy, Darra Dunn, Rahul Ray
• Journal: Journal of cellular biochemistry (J Cell Biochem) Vol. 99 Issue 3 Pg. 665-70 (Oct 15 2006) ISSN: 0730-2312 [Print] United States
• PMID: 16795032 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2006 Wiley-Liss, Inc.

Chemical References

• Antineoplastic Agents, Hormonal
• Estrogen Receptor alpha
• Porphyrins
• Selective Estrogen Receptor Modulators
• tamoxifen-pyropheophorbide conjugate
• Tamoxifen
• Chlorophyll
• pyropheophorbide a

Topics

• Antineoplastic Agents, Hormonal (chemistry, pharmacology, therapeutic use)
• Breast Neoplasms (drug therapy, metabolism, pathology)
• Cell Line, Tumor (drug effects)
• Cell Survival
• Chlorophyll (analogs & derivatives, chemistry, pharmacology, therapeutic use)
• Estrogen Receptor alpha (metabolism)
• Female
• Humans
• Molecular Structure
• Photochemotherapy (methods)
• Porphyrins (chemistry, pharmacology, therapeutic use)
• Selective Estrogen Receptor Modulators (chemistry, pharmacology, therapeutic use)
• Tamoxifen (analogs & derivatives, chemistry, pharmacology, therapeutic use)