Synthesis and biological activity of amide derivatives of nimbolide.

Abstract

Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.

• Authors: B S Sastry, K Suresh Babu, T Hari Babu, S Chandrasekhar, P V Srinivas, A K Saxena, J Madhusudana Rao
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 16 Issue 16 Pg. 4391-4 (Aug 15 2006) ISSN: 0960-894X [Print] England
• PMID: 16793266 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amides
• Antineoplastic Agents
• Limonins
• Plant Extracts
• nimbolide

Topics

• Amides (chemistry)
• Antineoplastic Agents (pharmacology)
• Azadirachta (metabolism)
• Cell Line, Tumor
• Chemistry, Pharmaceutical (methods)
• Drug Design
• Humans
• Inhibitory Concentration 50
• Limonins (chemistry)
• Models, Chemical
• Plant Extracts (metabolism)
• Plant Leaves
• Plants, Medicinal (metabolism)