Abstract |
Cadherins are Ca2+-dependent transmembrane glycoproteins crucial for cell-cell adhesion in vertebrates and invertebrates. Classification of this superfamily due to their phylogenetic relationship is currently restricted to three major subfamilies: classical, desmosomal and protocadherins. Here we report evidence for a common phylogenetic origin of the kidney-specific Ksp- (Cdh16) and the intestine-specific LI- cadherin (Cdh17). Both genes consist of 18 exons and the positions of their exon-intron boundaries as well as their intron phases are perfectly conserved. We found an extensive paralogy of more than 40 megabases in mammals as well as teleost fish species encompassing the Ksp- and LI- cadherin genes. A comparable paralogy was not detected for other cadherin gene loci. These findings suggest that the Ksp- and LI- cadherin genes originated by chromosomal duplication early during vertebrate evolution and support our assumption that both proteins are paralogues within a separate cadherin family that we have termed 7D-cadherins.
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Authors | M W Wendeler, R Jung, H Himmelbauer, R Gessner |
Journal | Cellular and molecular life sciences : CMLS
(Cell Mol Life Sci)
Vol. 63
Issue 13
Pg. 1564-73
(Jul 2006)
ISSN: 1420-682X [Print] Switzerland |
PMID | 16791429
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cadherins
- Cdh16 protein, mouse
- Cdh17 protein, mouse
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Topics |
- Animals
- Cadherins
(genetics, metabolism)
- Chromosome Mapping
- Cloning, Molecular
- Evolution, Molecular
- Exons
(genetics)
- Gene Duplication
- Introns
(genetics)
- Kidney
(metabolism)
- Mice
- Phylogeny
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