Cystic beta2-microglobulin amyloidoma in a patient on long-term hemodialysis.

Abstract

We report a patient with beta2 microglobulin amyloidosis (beta2M) in whom cystic tumors were seen in the bilateral axillary region. The patient was a 68-year-old woman who had been on hemodialysis for more than 20 years because of IgA nephropathy. Computed tomography-guided biopsy was performed to confirm the diagnosis. Congo red staining, beta2M immunohistochemistry, and electron microscopy examination of the biopsied sample showed extended beta2M deposits in the cystic tumor. beta2M-related amyloidosis in patients with long-term dialysis commonly presents as osteoarticular disease, although a soft-tissue pseudotumor, known as amyloidoma, has been reported. This is the first report in the English-language literature of amyloidosis presenting as bilateral axillary cystic tumors.

• Authors: Hiroaki Ogata, Fumihiko Koiwa, Junko Takahashi, Ken Takahashi, Akira Shiokawa, Takashi Kitanosono, Eriko Kinugasa, Susumu Taguchi
• Journal: Clinical and experimental nephrology (Clin Exp Nephrol) Vol. 10 Issue 2 Pg. 159-61 (Jun 2006) ISSN: 1342-1751 [Print] Japan
• PMID: 16791406 (Publication Type: Case Reports, Journal Article)

Chemical References

• beta 2-Microglobulin

Topics

• Aged
• Amyloidosis (etiology, pathology)
• Axilla (pathology)
• Cysts (etiology)
• Female
• Glomerulonephritis, IGA (therapy)
• Humans
• Renal Dialysis (adverse effects)
• beta 2-Microglobulin (immunology)