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Multihormonal resistance to parathyroid hormone, thyroid stimulating hormone, and other hormonal and neurosensory stimuli in patients with pseudohypoparathyroidism.

Abstract
In patients with pseudohypoparathyroidism, hormonal resistance first affects parathyroid hormone (PTH), which leads to calcipenia, a decrease in renal vitamin D activation, and a tendency to bone receptor remodeling. However, because G proteins are ubiquitously distributed, multiple hormonal resistance occurs in pseudohypoparathyroidism type Ia and type Ic, impairing responses to other calciotropic hormones (PTHrP, calcitonin), TSH, and also pituitary and hypothalamic hormones, and to neurosensory stimuli. The diversity of multihormonal resistance contributes to the various phenotypes of the disease. Some clinical discomfort and medical consequences of the disease can be treated or prevented with hormone supplementation or modulation.
AuthorsJean-Louis Wémeau, Anne-Sophie Balavoine, Miriam Ladsous, Fritz-Line Velayoudom-Cephise, Virginie Vlaeminck-Guillem
JournalJournal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 19 Suppl 2 Pg. 653-61 (May 2006) ISSN: 0334-018X [Print] Germany
PMID16789631 (Publication Type: Journal Article, Review)
Chemical References
  • Hormones
  • Parathyroid Hormone
  • Parathyroid Hormone-Related Protein
  • Receptors, Calcium-Sensing
  • Thyrotropin
Topics
  • Hearing
  • Hormones (physiology)
  • Humans
  • Parathyroid Hormone (physiology)
  • Parathyroid Hormone-Related Protein (metabolism)
  • Phenotype
  • Pseudohypoparathyroidism (classification, metabolism, physiopathology)
  • Receptors, Calcium-Sensing (metabolism)
  • Sensory Thresholds (physiology)
  • Smell
  • Taste
  • Thyrotropin (physiology)
  • Vision, Ocular

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