HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer.

AbstractBACKGROUND AND OBJECTIVES:
Interstitial photodynamic therapy (PDT) is an emerging modality for the treatment of solid organ disease. Our group at the University of Pennsylvania has performed extensive studies that demonstrate the feasibility of interstitial PDT for prostate cancer. Our preclinical and clinical experience is herein detailed.
STUDY DESIGN/MATERIALS AND METHODS:
We have treated 16 canines in preclinical studies, and 16 human subjects in a Phase I study, using motexafin lutetium-mediated PDT for recurrent prostate adenocarcinoma. Dosimetry of light fluence, drug level and oxygen distribution for these patients were performed.
RESULTS:
We demonstrate the safe and comprehensive treatment of the prostate using PDT. However, there is significant variability in the dose distribution and the subsequent tissue necrosis throughout the prostate.
CONCLUSIONS:
PDT is an attractive option for the treatment of prostate adenocarcinoma. However, the observed variation in PDT dose distribution translates into uncertain therapeutic reproducibility. Our future focus will be on the development of an integrated system that is able to both detect and compensate for dose variations in real-time, in order to deliver a consistent overall PDT dose distribution.
AuthorsK L Du, R Mick, T M Busch, T C Zhu, J C Finlay, G Yu, A G Yodh, S B Malkowicz, D Smith, R Whittington, D Stripp, S M Hahn
JournalLasers in surgery and medicine (Lasers Surg Med) Vol. 38 Issue 5 Pg. 427-34 (Jun 2006) ISSN: 0196-8092 [Print] United States
PMID16788929 (Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright 2006 Wiley-Liss, Inc.
Chemical References
  • Hemoglobins
  • Metalloporphyrins
  • Photosensitizing Agents
  • motexafin lutetium
  • Oxygen
Topics
  • Adenocarcinoma (drug therapy)
  • Aged
  • Animals
  • Dogs
  • Dose-Response Relationship, Drug
  • Hemoglobins (metabolism)
  • Humans
  • Male
  • Metalloporphyrins (administration & dosage, pharmacokinetics)
  • Middle Aged
  • Necrosis
  • Neoplasm Recurrence, Local (drug therapy)
  • Oxygen (blood)
  • Photochemotherapy
  • Photosensitizing Agents (administration & dosage, pharmacokinetics)
  • Prostate (blood supply, metabolism, pathology)
  • Prostatic Neoplasms (drug therapy)
  • Regional Blood Flow (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: