Abstract | OBJECTIVE: STUDY DESIGN: Comparative study. SETTING: University hospital and affiliated hospital. PATIENTS: Ten sequential SSNHL patients with diabetes receiving IT-DEX and 21 sequential SSNHL patients with diabetes receiving IV-DEX. Patients with low tone hearing loss were excluded. INTERVENTION: In the IT-DEX group, two methods were applied to deliver DEX (4 mg/ml): injection through a perforation made by laser-assisted myringotomy or through a tympanostomy tube. IT-DEX administration was performed on 8 sequential days. In the IV-DEX group, DEX was administrated intravenously starting from an amount of 8 mg/d followed by taped doses for 10 days. MAIN OUTCOME MEASURES: Preprocedure and postprocedure hearing levels and complications. RESULTS: In the IT-DEX group, the average hearing level before the treatment was 79 dB. Overall, all 10 patients showed improvement of more than 10 dB in the pure-tone audiogram, with a mean improvement of 41 dB. Seven patients (70%) demonstrated successful results, and four recovered completely. In the IV-DEX group, 14 (67%) of the 21 patients showed improvement of more than 10 dB with a mean improvement of 25 dB. Thirteen patients (62%) demonstrated successful results. Free blood sugar during and after the IT-DEX treatment remained below the pretreatment levels, whereas four patients in the IV-DEX group demonstrated worsening of the hyperglycemia. CONCLUSION: IT-DEX treatment is at least as effective as IV-DEX treatment for SSNHL patients with diabetes.
|
Authors | Seiji Kakehata, Akira Sasaki, Kasumi Oji, Kazunori Futai, Shuji Ota, Kimitoshi Makinae, Hideichi Shinkawa |
Journal | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
(Otol Neurotol)
Vol. 27
Issue 5
Pg. 604-8
(Aug 2006)
ISSN: 1531-7129 [Print] United States |
PMID | 16788418
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Glucocorticoids
- Dexamethasone
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Dexamethasone
(administration & dosage, therapeutic use)
- Diabetes Complications
(drug therapy)
- Female
- Glucocorticoids
(administration & dosage, therapeutic use)
- Hearing Loss, Sensorineural
(drug therapy)
- Hearing Loss, Sudden
(drug therapy)
- Humans
- Injections, Intravenous
- Laser Therapy
- Male
- Middle Aged
- Middle Ear Ventilation
- Treatment Outcome
- Tympanic Membrane
(surgery)
|