Abstract | OBJECTIVE: METHODS: RESULTS: There were increases in glomerular infiltration of leukocyte, expressions of IL-1beta and IL-6 protein and mRNA, and activities of NF-kappaB in nephritic rats between days 1 and 4 after nephritis induction. The enhanced proteinuria, score of mesangial proliferation, glomerular PCNA positive cells, activities of phosphorylated PI3-K, Akt1 and STAT3, and reduced p27(kip1) expression were found on day 4 after nephritis induction. 15-Methyl-LXA4 treatment significantly reduced the proteinuria, glomerular infiltration of leukocyte, expressions of IL-1beta and IL-6 protein and mRNA, score of mesangial proliferation, glomerular PCNA positive cells, activities of phosphorylated PI3-K, Akt1, NF-kappaB and STAT3, and increased the p27(kip1) expression. CONCLUSIONS:
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Authors | Sheng-Hua Wu, Pei-Yuan Liao, Ling Dong, Xin-You Jiang |
Journal | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
(Zhongguo Dang Dai Er Ke Za Zhi)
Vol. 8
Issue 3
Pg. 225-30
(Jun 2006)
ISSN: 1008-8830 [Print] China |
PMID | 16787597
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- 15-methyl-lipoxin A4
- Interleukin-1
- Interleukin-6
- Lipoxins
- NF-kappa B
- RNA, Messenger
- STAT3 Transcription Factor
- DNA
- Phosphatidylinositol 3-Kinases
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Topics |
- Animals
- DNA
(metabolism)
- Female
- Glomerulonephritis, Membranoproliferative
(drug therapy)
- Interleukin-1
(genetics)
- Interleukin-6
(genetics)
- Lipoxins
(therapeutic use)
- NF-kappa B
(metabolism)
- Phosphatidylinositol 3-Kinases
(physiology)
- RNA, Messenger
(analysis)
- Rats
- Rats, Inbred Lew
- STAT3 Transcription Factor
(metabolism)
- Signal Transduction
(drug effects)
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